DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression
Identifieur interne : 000082 ( France/Analysis ); précédent : 000081; suivant : 000083DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression
Auteurs : Dilys Lam [Australie] ; Marie-Laure Ancelin [France] ; Karen Ritchie [Royaume-Uni] ; Richard Saffery [Australie] ; Joanne Ryan [Australie]Source :
- Psychoneuroendocrinology [ 0306-4530 ] ; 2018.
English descriptors
- mix :
Abstract
BackgroundDepression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.ObjectiveTo investigate ACE promoter methylation as a biomarker of late-life depression, and its association with genetic variation and cortisol secretion.MethodThe longitudinal general population ESPRIT study is aimed at investigating psychiatric disorders in older persons (n = 1863, average age = 73). Depression was assessed using the Mini International Neuropsychiatric Interview according to DSM-IV criteria and the Centre for Epidemiologic Studies Depression Scale (CES-D). Genotype information for seven polymorphisms across the ACE gene was also available. Blood and saliva samples collected at baseline and used to extract DNA and measure cortisol, respectively. Sequenom MassARRAY was used to measure promoter DNA methylation of the ACE gene (n = 552).ResultsThere was no evidence of an association between ACE promoter methylation and depression. However, there was evidence that ACE genetic variants influenced methylation, and modified the association between depression and methylation (Δ at various sites; ‐2.05% to 1.74%; p = 0.019 to 0.039). Multivariate analyses were adjusted for participants’ lifestyle, health and medical history. Independent of depression status, ACE methylation was inversely correlated with cortisol levels (r = −0.336, p = 0.042).ConclusionThis study provides evidence that associations between ACE methylation and depression are genotype-dependent, suggesting that the development of reliable depression biomarkers may need to consider methylation levels in combination with underlying genetic variation. ACE methylation may also be a suitable biomarker of cortisol and/or HPA axis activity.
Url:
DOI: 10.1016/j.psyneuen.2017.11.003
Affiliations:
- Australie, France, Royaume-Uni
- Languedoc-Roussillon, Occitanie (région administrative), Victoria (État), Écosse
- Melbourne, Montpellier, Édimbourg
- PRES Sud de France, Université Montpellier 1, Université d'Édimbourg, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000025
- to stream Hal, to step Curation: 000025
- to stream Hal, to step Checkpoint: 000043
- to stream Main, to step Merge: 000943
- to stream Main, to step Curation: 000942
- to stream Main, to step Exploration: 000942
- to stream France, to step Extraction: 000082
Links to Exploration step
Hal:hal-02398382Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression</title><author><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-521570" status="INCOMING"> <orgName>Cancer & Disease Epigenetics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-306322" type="direct"></relation> <relation active="#struct-335176" type="direct"></relation> <relation active="#struct-521569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306322" type="direct"><org type="institution" xml:id="struct-306322" status="VALID"> <orgName>University of Melbourne</orgName> <desc> <address> <addrLine>Parkville VIC 3010</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unimelb.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-335176" type="direct"><org type="institution" xml:id="struct-335176" status="VALID"> <orgName>Murdoch Children's Research Institute</orgName> <orgName type="acronym">MCRI</orgName> <desc> <address> <addrLine>Royal Children’s Hospital, Flemington Rd, Parkville VIC 3052, Australie</addrLine> <country key="AU"></country> </address> <ref type="url">https://www.mcri.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-521569" type="direct"><org type="institution" xml:id="struct-521569" status="INCOMING"> <orgName>Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-493426" status="INCOMING"> <orgName>Centre For Clinical Brain Sciences - Neuroimaging Sciences [Edinburgh, U.K.]</orgName> <orgName type="acronym">CCBS</orgName> <desc> <address> <addrLine>49 Little france Crescent, Edinburgh EH6 8SP</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ed.ac.uk/schools-departments/clinical-brain-sciences</ref> </desc> <listRelation> <relation active="#struct-61277" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-61277" type="direct"><org type="institution" xml:id="struct-61277" status="VALID"> <orgName>University of Edinburgh</orgName> <desc> <address> <addrLine>Old College South Bridge Edinburgh EH8 9YL</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ed.ac.uk/home</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-521570" status="INCOMING"> <orgName>Cancer & Disease Epigenetics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-306322" type="direct"></relation> <relation active="#struct-335176" type="direct"></relation> <relation active="#struct-521569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306322" type="direct"><org type="institution" xml:id="struct-306322" status="VALID"> <orgName>University of Melbourne</orgName> <desc> <address> <addrLine>Parkville VIC 3010</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unimelb.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-335176" type="direct"><org type="institution" xml:id="struct-335176" status="VALID"> <orgName>Murdoch Children's Research Institute</orgName> <orgName type="acronym">MCRI</orgName> <desc> <address> <addrLine>Royal Children’s Hospital, Flemington Rd, Parkville VIC 3052, Australie</addrLine> <country key="AU"></country> </address> <ref type="url">https://www.mcri.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-521569" type="direct"><org type="institution" xml:id="struct-521569" status="INCOMING"> <orgName>Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-469589" status="VALID"> <orgName>Monash University [Melbourne]</orgName> <desc> <address> <addrLine>Victoria 3800, Australia </addrLine> <country key="AU"></country> </address> <ref type="url">https://www.monash.edu/</ref> </desc> </hal:affiliation><country>Australie</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02398382</idno><idno type="halId">hal-02398382</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-02398382</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-02398382</idno><idno type="doi">10.1016/j.psyneuen.2017.11.003</idno><date when="2018">2018</date><idno type="wicri:Area/Hal/Corpus">000025</idno><idno type="wicri:Area/Hal/Curation">000025</idno><idno type="wicri:Area/Hal/Checkpoint">000043</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000043</idno><idno type="wicri:doubleKey">0306-4530:2018:Lam D:dna:methylation:and</idno><idno type="wicri:Area/Main/Merge">000943</idno><idno type="wicri:Area/Main/Curation">000942</idno><idno type="wicri:Area/Main/Exploration">000942</idno><idno type="wicri:Area/France/Extraction">000082</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression</title><author><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-521570" status="INCOMING"> <orgName>Cancer & Disease Epigenetics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-306322" type="direct"></relation> <relation active="#struct-335176" type="direct"></relation> <relation active="#struct-521569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306322" type="direct"><org type="institution" xml:id="struct-306322" status="VALID"> <orgName>University of Melbourne</orgName> <desc> <address> <addrLine>Parkville VIC 3010</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unimelb.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-335176" type="direct"><org type="institution" xml:id="struct-335176" status="VALID"> <orgName>Murdoch Children's Research Institute</orgName> <orgName type="acronym">MCRI</orgName> <desc> <address> <addrLine>Royal Children’s Hospital, Flemington Rd, Parkville VIC 3052, Australie</addrLine> <country key="AU"></country> </address> <ref type="url">https://www.mcri.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-521569" type="direct"><org type="institution" xml:id="struct-521569" status="INCOMING"> <orgName>Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-139836" status="VALID"> <idno type="RNSR">201120699F</idno> <orgName>Neuropsychiatrie : recherche épidémiologique et clinique</orgName> <desc> <address> <addrLine>Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-42570" type="direct"></relation> <relation name="U1061" active="#struct-303623" type="direct"></relation> <relation active="#struct-410122" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-42570" type="direct"><org type="institution" xml:id="struct-42570" status="OLD"> <orgName>Université Montpellier 1</orgName> <orgName type="acronym">UM1</orgName> <date type="end">2014-12-31</date> <desc> <address> <addrLine>5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-montp1.fr/</ref> </desc> </org></tutelle><tutelle name="U1061" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-410122" type="direct"><org type="institution" xml:id="struct-410122" status="VALID"> <idno type="ISNI">0000000120970141</idno> <orgName>Université de Montpellier</orgName> <orgName type="acronym">UM</orgName> <desc> <address> <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.umontpellier.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName><orgName type="university">Université Montpellier 1</orgName><orgName type="institution" wicri:auto="newGroup">PRES Sud de France</orgName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-493426" status="INCOMING"> <orgName>Centre For Clinical Brain Sciences - Neuroimaging Sciences [Edinburgh, U.K.]</orgName> <orgName type="acronym">CCBS</orgName> <desc> <address> <addrLine>49 Little france Crescent, Edinburgh EH6 8SP</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ed.ac.uk/schools-departments/clinical-brain-sciences</ref> </desc> <listRelation> <relation active="#struct-61277" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-61277" type="direct"><org type="institution" xml:id="struct-61277" status="VALID"> <orgName>University of Edinburgh</orgName> <desc> <address> <addrLine>Old College South Bridge Edinburgh EH8 9YL</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ed.ac.uk/home</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-521570" status="INCOMING"> <orgName>Cancer & Disease Epigenetics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> <listRelation> <relation active="#struct-306322" type="direct"></relation> <relation active="#struct-335176" type="direct"></relation> <relation active="#struct-521569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306322" type="direct"><org type="institution" xml:id="struct-306322" status="VALID"> <orgName>University of Melbourne</orgName> <desc> <address> <addrLine>Parkville VIC 3010</addrLine> <country key="AU"></country> </address> <ref type="url">http://www.unimelb.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-335176" type="direct"><org type="institution" xml:id="struct-335176" status="VALID"> <orgName>Murdoch Children's Research Institute</orgName> <orgName type="acronym">MCRI</orgName> <desc> <address> <addrLine>Royal Children’s Hospital, Flemington Rd, Parkville VIC 3052, Australie</addrLine> <country key="AU"></country> </address> <ref type="url">https://www.mcri.edu.au/</ref> </desc> </org></tutelle><tutelle active="#struct-521569" type="direct"><org type="institution" xml:id="struct-521569" status="INCOMING"> <orgName>Royal Children’s Hospital & Department of Paediatrics [Parkville, VIC, Australia]</orgName> <desc> <address> <country key="AU"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-469589" status="VALID"> <orgName>Monash University [Melbourne]</orgName> <desc> <address> <addrLine>Victoria 3800, Australia </addrLine> <country key="AU"></country> </address> <ref type="url">https://www.monash.edu/</ref> </desc> </hal:affiliation><country>Australie</country></affiliation></author></analytic><idno type="DOI">10.1016/j.psyneuen.2017.11.003</idno><series><title level="j">Psychoneuroendocrinology</title><idno type="ISSN">0306-4530</idno><imprint><date type="datePub">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Angiotensin converting enzyme (ACE)</term><term>Cortisol</term><term>DNA methylation</term><term>Depression</term><term>Epigenetics</term><term>Genetic variation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BackgroundDepression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic regulation of ACE may play an important role in HPA axis (dys)regulation.ObjectiveTo investigate ACE promoter methylation as a biomarker of late-life depression, and its association with genetic variation and cortisol secretion.MethodThe longitudinal general population ESPRIT study is aimed at investigating psychiatric disorders in older persons (n = 1863, average age = 73). Depression was assessed using the Mini International Neuropsychiatric Interview according to DSM-IV criteria and the Centre for Epidemiologic Studies Depression Scale (CES-D). Genotype information for seven polymorphisms across the ACE gene was also available. Blood and saliva samples collected at baseline and used to extract DNA and measure cortisol, respectively. Sequenom MassARRAY was used to measure promoter DNA methylation of the ACE gene (n = 552).ResultsThere was no evidence of an association between ACE promoter methylation and depression. However, there was evidence that ACE genetic variants influenced methylation, and modified the association between depression and methylation (Δ at various sites; ‐2.05% to 1.74%; p = 0.019 to 0.039). Multivariate analyses were adjusted for participants’ lifestyle, health and medical history. Independent of depression status, ACE methylation was inversely correlated with cortisol levels (r = −0.336, p = 0.042).ConclusionThis study provides evidence that associations between ACE methylation and depression are genotype-dependent, suggesting that the development of reliable depression biomarkers may need to consider methylation levels in combination with underlying genetic variation. ACE methylation may also be a suitable biomarker of cortisol and/or HPA axis activity.</p> </div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li><li>Écosse</li></region><settlement><li>Melbourne</li><li>Montpellier</li><li>Édimbourg</li></settlement><orgName><li>PRES Sud de France</li><li>Université Montpellier 1</li><li>Université d'Édimbourg</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Lam, Dilys" sort="Lam, Dilys" uniqKey="Lam D" first="Dilys" last="Lam">Dilys Lam</name></region><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name></region></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000082 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000082 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= France
|étape= Analysis
|type= RBID
|clé= Hal:hal-02398382
|texte= DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression
}}
| This area was generated with Dilib version V0.6.33. |  |